Targeting kidney cell senescence: a new paradigm for the treatment of chronic kidney disease?

From Top Italian Scientists Journal
Published
June 6, 2024
Title
Targeting kidney cell senescence: a new paradigm for the treatment of chronic kidney disease?
Authors
Giacomo Garibotto, Pasquale Esposito, Daniela Picciotto, Daniela Verzola, Francesca Costigliolo, Valentina Zanetti, Michela Saio, Elisa Russo, Francesca Viazzi
DOI
10.62684/FJDT9733
Keywords
chronic kidney disease; kidney cell senescence.
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Giacomo Garibotto(a), Pasquale Esposito(a,b), Daniela Picciotto(b), Daniela Verzola(a), Francesca Costigliolo(b), Valentina Zanetti(a,b), Michela Saio(b), Elisa Russo(a,b), Francesca Viazzi(a,b)

Department of Internal Medicine, University of Genova (a), Division of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Genova (b)

Correspondence to: Giacomo Garibotto MD, Department of Internal Medicine, Università degli Studi di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy. email:gari@unige.it

Abstract

Cellular senescence is a condition where cells undergo a permanent cell cycle arrest, accompanied by a unique set of functional and morphological changes. While initial studies of senescence have largely focused on its role as a barrier to extended cell division and tumorigenesis, in recent years cell senescence has emerged as an important driver of aging and age-related disease in different tissues, including the kidney. Accelerated cell senescence may decrease kidney repair capacity because of cell cycle arrest; in addition cell senescence promotes glomerulosclerosis and tubulointerstitial fibrosis via the production and release of proinflammatory and matrix-degrading molecules. Although almost all glomerular and tubular cells may undergo senescent changes, the glomerular podocytes and proximal tubule cells are the most commonly affected cells. In these days, treating cell senescence is moving his steps from the preclinical to the clinical stage. While cell senescence appears to be well accepted as a new mechanism for kidney damage and chronic kidney disease [CKD] progression, there still are many unanswered questions regarding how to dectect it in kidney biopsies, which is prognostic meaning of individual kidney senescnce markers, which the role of different cells involved, as well as the efficacy of the emerging senescence-targeted therapies on the progression and complications of CKD.

Declarations

Conflict of Interest

The Authors declare that there is no conflict of interest.

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