Radiation injuries in people and animals: A lot of food for thought

From Top Italian Scientists Journal
Published
September 1, 2025
Title
Radiation injuries in people and animals: A lot of food for thought
Author
Giovanni Di Guardo
DOI
10.62684/HWTF3503
Keywords
Radiation-induced acute effects, chronic biological effects, war theatres in Ukraine and Middle East, p53.
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Giovanni Di Guardo

Former Professor of General Pathology and Veterinary Pathophysiology at the Veterinary Medical Faculty of the University of Teramo, Località Piano d’Accio, 64100 Teramo, Italy.

Correspondence to: gdiguardo@unite.it

Abstract

The present Editorial deals with radiation-induced acute and chronic biological effects in humans and in animals, to which special attention should be also paid in view of the ongoing war theatres in Ukraine as well as in Near and Middle East.

Within this challenging and frightening scenario, emphasis is placed upon chronic radiation-induced effects, with particular reference to tumour development, on one hand, and to protective host cells' mechanisms like p53, on the other hand, within a One Health perspective.

Declarations

Conflict of Interest

The Author declares that there is no conflict of interest.

References

  1. Cheville NF. Introduction to Veterinary Pathology, 3rd Edition, Wiley-Blackwell, Hoboken, NJ, USA, pp. 1-384 (2006).
  2. Gerber GB, Wick RR, Watson CR, Gössner W, Kellerer AM. International radiobiology archives of long-term animal studies: Structure, possible uses and potential extension. Radiat. Environ. Biophys. 1999;38:75-79. DOI:10.1007/s004110050141.
  3. Sazykina TG. Population sensitivities of animals to chronic ionizing radiation-model predictions from mice to elephant. J. Environ. Radioact. 2018;182:177-182. DOI:10.1016/j.jenvrad.2017.11.013.
  4. Russo IH, Russo J. Mammary gland neoplasia in long-term rodent studies. Environ. Health Perspect. 1996;104:938-967. DOI:10.1289/ehp.96104938.
  5. Foiani G, Licenziato L, Marconato L, Fanelli A, Melchiotti E, Zanardello C, Aresu L, Vascellari M. Predictive value of TP53 RNAscope®in situ hybridization and p53 immunohistochemistry for TP53 mutational status in canine diffuse large B-cell lymphoma. Vet. Q. 2024;44:1-9. DOI:10.1080/01652176.2024.2403453.
  6. Rodrigues L, Wu K, Harvey G, Post G, Miller A, Hull A, Lambert L, Lopes C, Zou J. Real-world evidence couples genomic biomarkers with therapeutic outcomes for canine hemangiosarcoma. Sci. Rep. 2025;15(1):16442. DOI:10.1038/s41598-025-89862-9.
  7. Abegglen LM, Caulin AF, Chan A, Lee K, Robinson R, Campbell MS, Kiso WK, Schmitt DL, Waddell PJ, Bhaskara S, Jensen ST, Maley CC, Schiffman JD. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. J. Am. Med. Assoc. 2015;314:1850-1860. DOI:10.1001/jama.2015.13134.