Bioinformatic Sweeties: a unified portal for characterizing human proteins and their variants

From Top Italian Scientists Journal
March 6, 2024
Bioinformatic Sweeties: a unified portal for characterizing human proteins and their variants
Giulia Babbi, Matteo Manfredi, Elisa Bertolini, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio
protein annotation, functional annotation, variant annotation, predictors, diseases
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Giulia Babbi, Matteo Manfredi, Elisa Bertolini, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio

Biocomputing Group, University of Bologna

Correspondence to: Rita Casadio,


Next-generation sequencing techniques provide an unprecedented characterisation of human Variants of Unknown Significance (VUS). Single-residue variations are collected in public databases and associated to diseases and phenotypes. However, for detailing at molecular level mechanisms involved in the onset of diseases, variants need structural and functional annotation. Here we propose a new portal called Bioinformatic Sweeties, collecting resources ranging from databases for human protein annotation to computational methods for predicting impact of variants. The tools, included in the portal, allow computing different protein properties, ranging from solvent accessible surface to stability and interactions and do not require login or installation. The portal, speeding up the variant characterisation process, is available at:



GB: Project title: "National Center for HPC, Big Data and Quantum Computing", code: CN00000013, CUP: J33C22001170001. Funded by the European Union - NextGenerationEU, PNRR - Mission 4 - Component 2 - Investment 1.4 "Strengthening research structures and creation of "national R&D champions" on some Key Enabling Technologies" D.D. 3138 of 12/16/2021 corrected with D.D. 3175 of 12/18/2021.

Conflict of Interest Declaration

The authors declare no conflict of interest.


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