Normogonadotropic azoospermia: the puzzle of hormonal treatment
| Published |
| October 7, 2025 |
| Title |
| Normogonadotropic azoospermia: the puzzle of hormonal treatment |
| Authors |
| Sandro La Vignera, Rosita A. Condorelli |
| DOI |
| 10.62684/TKCW4052 |
| Downloads |
 |
Sandro La Vignera (a), Rosita A. Condorelli (b)
(a) Full Professor of Endocrinology University of Catania (Italy), sandrolavignera@unict.it
(b) Associate Professor of Endocrinology University of Catania (Italy), rosita.condorelli@unict.it
Correspondence to: Sandro La Vignera, email: sandrolavignera@unict.it
Abstract
The editorial proposes an original algorithm for hormonal treatment of patients with normogonadotropic azoospermia (NOAN). This condition is very common in clinical practice, and the approach of endocrinologists varies. Different therapeutic strategies are recommended based on clinical (testicular volume and body mass index) and hormonal parameters (inhibin B and 17-alpha hydroxyprogesterone levels). The algorithm suggests the role of follicle-stimulating hormone or chorionic gonadotropin, or incretin therapy, which are fully included in the potential therapeutic proposal due to the significant repercussions of metabolic syndrome and obesity on sperm quality.
Declarations
Conflict of Interest
The Authors declare that there is no conflict of interest.
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