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https://journal.topitalianscientists.org/The_rational_of_a_fixed_combination_of_benzoyl_peroxide_and_niacinamide_in_the_treatment_of_acne_vulgaris_A_narrative_review
{{DISPLAYTITLE:The “Black Swan Principle” and the Genetics of Complex Diseases}}
 
 
{{DISPLAYTITLE:Rationale and design of a prospective, open-label, randomized, multicentric clinical trial on the role of drug-coated balloons for bifurcation coronary lesions: the PRO-DAVID study}}
{{#seo:
{{#seo:
|title=Rationale and design of a prospective, open-label, randomized, multicentric clinical trial on the role of drug-coated balloons for bifurcation coronary lesions: the PRO-DAVID study - Top Italian Scientists Journal
|title=The “Black Swan Principle” and the Genetics of Complex Diseases - Top Italian Scientists Journal
|description=coronary bifurcation lesions (CBL) are associated with impaired outcome. The role of drug-coated balloons (DCB) in this setting has been only investigated in small studies so far.
|description=The black swan principle is a philosophy theory created by Nassim Nicholas Taleb that seeks to explain rare and unpredictable events, appearances that seem to defy logic or rational explanation.
|keywords=DCB; coronary bifurcations; study design
|keywords=Black Swan Principle; Genetics of Complex Diseases
|citation_author=Prvulović, Đeiti; Cortese, Bernardo
|citation_author=Novelli, Giuseppe; Reichardt, Juergen K V
|citation_journal_title=Top Italian Scientists Journal  
|citation_journal_title=Top Italian Scientists Journal  
|citation_publication_date=2024/01/14
|citation_publication_date=2024/01/13
|citation_title=Rationale and design of a prospective, open-label, randomized, multicentric clinical trial on the role of drug-coated balloons for bifurcation coronary lesions: the PRO-DAVID study
|citation_title=The “Black Swan Principle” and the Genetics of Complex Diseases
|citation_keywords=DCB; coronary bifurcations; study design
|citation_keywords=Black Swan Principle; Genetics of Complex Diseases
|citation_publisher=Top Italian Scientists
|citation_publisher=Top Italian Scientists
|citation_volume=1
|citation_volume=1
|citation_issue=1
|citation_issue=1
|citation_pdf_url=https://journal.topitalianscientists.org/images/5/53/The_Black_Swan_Principle_and_the_Genetics_of_Complex_Diseases.pdf
|citation_abstract_html_url=https://journal.topitalianscientists.org/The_Black_Swan_Principle_and_the_Genetics_of_Complex_Diseases
|citation_doi=-
|citation_doi=-
|citation_issn=3033-5132
|}}
|}}
{| class="wikitable" style="float:right ;border:solid 1px #a2a9b1; background-color: #f8f9fa" cellpadding="5"
{| class="wikitable" style="float:right ;border:solid 1px #a2a9b1; background-color: #f8f9fa" cellpadding="5"
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| '''Published'''
| '''Published'''
|-
|-
| January 14, 2024
| January 13, 2024
|-
|-
| '''Title'''  
| '''Title'''  
|-
|-
| style="width:200px;" | Rationale and design of a prospective, open-label, randomized, multicentric clinical trial on the role of drug-coated balloons for bifurcation coronary lesions: the PRO-DAVID study
| style="width:200px;" | The “Black Swan Principle” and the Genetics of Complex Diseases
|-  
|-  
| '''Authors'''
| '''Authors'''
|-
|-
| Đeiti Prvulović, MD<sup>(a)</sup> [https://topitalianscientists.org/tis/49116/Bernardo_Cortese_-_Top_Italian_Scientist_in_Clinical_Sciences Bernardo Cortese], MD<sup>(b,c)</sup>
|   Giuseppe Novelli, Juergen K V Reichardt
|-
|-
| '''Keywords'''
| '''Keywords'''
|-
|-
| DCB; coronary bifurcations; study design
| Black Swan Principle; Genetics of Complex Diseases
|-
|-
| '''Downloads'''
| '''Downloads'''
|-
|-
|  style="text-align: center;" | [[File:PDF_file_icon.png|center|50px|'''Download PDF'''|link=https://files.topitalianscientists.org/journal/01-01/Rationale_and_design_of_a_prospect_Bernardo_Cortese.pdf]]
|  style="text-align: center;" | [[File:PDF_file_icon.png|center|50px|'''Download PDF'''|link=https://journal.topitalianscientists.org/images/5/53/The_Black_Swan_Principle_and_the_Genetics_of_Complex_Diseases.pdf]]
|}
|}
'''[https://topitalianscientists.org/tis/2359/Giuseppe_Novelli_-_Top_Italian_Scientist_in_Biomedical_Sciences Giuseppe Novelli]'''<sup>(a)</sup>, '''Juergen K V Reichardt'''<sup>(b)</sup>


Đeiti Prvulović, MD<sup>(a)</sup> [https://topitalianscientists.org/tis/49116/Bernardo_Cortese_-_Top_Italian_Scientist_in_Clinical_Sciences Bernardo Cortese], MD<sup>(b,c)</sup>
<sup>(a)</sup>Department of Biomedicine and Prevention, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy and Department of Pharmacology, School of Medicine, University of Nevada, 89557, Reno, NV, USA.
 
<sup>(a)</sup>Clinical Hospital Center Rijeka, Rijeka, Croatia
 
<sup>(b)</sup>Fondazione Ricerca e Innovazione Cardiovascolare, Milano, Italy
 
<sup>(c)</sup>DCB Academy, Milano, Italy
 
'''Fundings''': none.


'''Disclosures''': none.
<sup>(b)</sup>Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, 4878, Australia.


'''Address for correspondence''': Bernardo Cortese, MD, FESC, Cardiovascular Research Group, Fondazione Ricerca e Innovazione Cardiovascolare, Milano, Italy. Via E. Ponti 49, Milano, Italy. bcortese@gmail.com - Running head: DCB use for coronary bifurcations.
''Correspondence to'': novelli@med.uniroma2.it


'''Declaration of interest''': none.
==Abstract==
The black swan principle is a philosophy theory created by Nassim Nicholas Taleb that seeks to explain rare and unpredictable events, appearances that seem to defy logic or rational explanation. These events, termed "Black Swans," have been observed in various domains, including finance, public administration, infectious diseases, and ecology. The concept of Black Swans has gained recently, significant attention in academia and practice due to its relevance in understanding extreme and rare occurrences. The “black swan” concept has been used in genetics for the unexpected developments that genome sequencing would reveal and which could have consequences for healthcare systems (e.g., increase in often unnecessary and inappropriate diagnostic investigations, increase in non-patients, etc.).

Latest revision as of 10:57, 2 June 2024

Published
January 13, 2024
Title
The “Black Swan Principle” and the Genetics of Complex Diseases
Authors
Giuseppe Novelli, Juergen K V Reichardt
Keywords
Black Swan Principle; Genetics of Complex Diseases
Downloads
Download PDF
Download PDF

Giuseppe Novelli(a), Juergen K V Reichardt(b)

(a)Department of Biomedicine and Prevention, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy and Department of Pharmacology, School of Medicine, University of Nevada, 89557, Reno, NV, USA.

(b)Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, 4878, Australia.

Correspondence to: novelli@med.uniroma2.it

Abstract

The black swan principle is a philosophy theory created by Nassim Nicholas Taleb that seeks to explain rare and unpredictable events, appearances that seem to defy logic or rational explanation. These events, termed "Black Swans," have been observed in various domains, including finance, public administration, infectious diseases, and ecology. The concept of Black Swans has gained recently, significant attention in academia and practice due to its relevance in understanding extreme and rare occurrences. The “black swan” concept has been used in genetics for the unexpected developments that genome sequencing would reveal and which could have consequences for healthcare systems (e.g., increase in often unnecessary and inappropriate diagnostic investigations, increase in non-patients, etc.).